Experiment 635419
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Aesculus hippocastanum (HIPPOCASTANACEAE) |
| Citation | DIEHM,C:. (1996). THE ROLE OF OEDEMA PROTECTIVE DRUGS IN THE TREATMENT DRUGS IN THE TREATMENT OF CHRONIC VENOUS INSUFFICIENCY: A REVIEW OF EVIDENCE BASED ON PLACEBO-CONTROLLED CLINICAL TRIALS WITH REGARD TO EFFICACY AND TOLERANCE.. 11() |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS STUDY DEMONSTRATES THAT THERAPY WITH DRIED HORSE-CHESTNUT SEED EXTRACT (HCSE, 50 MG AESCIN, TWICE DAILY) AND COMPRESSION STOCKING (CLASS2) RESULTED IN EQUIVALENT EFFICACY (OEDEMA REDUCTION). LOWER LEG VOLUME OF THE MORE SEVERELY AFFECTED LIMB DECREASED ON AVERAGE BY 43.8 ML(N=95)WITH HCSE AND 46.7 ML(N=99) WITH COMPRESSION THERAPY, WHILE IT INCREASED BY 9.8 ML WITH PLACEBO(9=46) AFTER 12 WEEKS THERAPY FOR THE INTENTION-TO-TREAT GROUP (95% CONFIDENCE INTERVALS: HCSE: 21.1 TO 66.4 , COMPRESSION: 30.4 TO 63.0, PLACEBO: -40.0 TO 20.4) SIGNIFICANT OEDEMA REDUCTIONS WERE ACHIEVED BY HCSE (P=0.005) AND COMPRESSION (P=0.002) COMPARED TO PLACEBO, AND THE TWO THERAPIES WERE SHOWN TO BE EQUIVALENT (P=0.001); IN THIS DESIGN, HOWEVER, COMPRESSION COULD NOT BE PROVEN AS STANDARD (RELEVANT SUPERIORITY) WITH REGARD TO OEDEMA REDUCTION IN THE STATISTICAL TEST PROCEDURE. BOTH HCSE AND COMPRESSION THERAPY WERE WELL TOLERATED AND NO SERIOUS TREATMENT-RELATED EVENTS WERE NOTED. |
| Dose amount | 600.0 MG |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |