Experiment 635427
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Tanacetum parthenium (ASTERACEAE) |
| Citation | VOGLER,BK: PITTLER,MH: ERNST,E:. (1998). FEVERFEW AS A PREVENTIVE TREATMENT FOR MIGRAINE: A SYSTEMATIC REVIEW.. 18() |
| Amount utilized | |
| Compound isolated | |
| Disease | A CROSSOVER CLINICAL TRIAL INVOLVING 57 PATIENTS. DURING THE PRELIMINARY PHASE OF THEIS STUDY EACY PATIENT WAS TREATED WITH 100 MG FEVERFEW DAILY FOR 2 MONTHS. THEREAFTER ONE GROUP RECEIVED PLACEBO FOR AN ADDITIONAL 30 DAYS, WHILE THE OTHER GROUP CONTINUED TAKING FEVERFEW. IN THE THIRD PHASE, THE TREATMENT GROUP WAS TRANSFERRED TO THE PLACEBO ARM AND VICE VERSA. NO WASHOUT PERIOD WAS INCLUDED. PAIN INTENSITY AND SEVERITY OF THE ACCOMPAYING SYMPTOMS SUCH AS NAUSEA, VOMITING, AND SENSITIVITY TO NOISE AND LIGHT WERE REPORTED. THE RESULTS IN THE PRELIMINARY PHASE SHOWED A SIGNIFICANT DECREASE IN PAIN INTENSITY AFTER THE TREATMENT WITH FEVERFEW COMPARED TO BASELINE (P<0.001). IN THE CROSSOVER PHASE A SIGNIFICANE REDUCTION OF PAIN INTENSITY WAS REPORTED IN THE TREATMENT GROUP COMPARED TO THE PLACEBO GROUP (-<0.01. IN ADDITION, THERE WAS A SIGNIFICANT REDUCTION (P<0.01) IN EACH OF THE ABOVE ACCOMPANYING SYMPTOMS. |
| Dose amount | 100.0 MG |
| Number | 5 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | LEAVES |
| Gender | GIVEN TO BOTH SEXES |