Experiment 635439
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | WANG,HL: ZOU,HF: KONG,LA: ZHANG,YK: PANG,HA: SU,CY: LIU,GY: HUI,M: FU,L:. (1999). DETERMINATION OF GINSENOSIDE RG3 IN PLASMA BY SOLID-PHASE EXTRACTION AND HIGH-EPRFORMANCE LIQUID CHROMATOGRAPHY FOR PHARMACOKINETIC STUDY.. 731(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | A METHOD USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) AND SOLID-PHASE EXTRACTION (SPE) IS DESCRIBED FOR THE DETERMINATION OF GINSENOSIDE RG3 IN HUMAN PLASMA 2.5-ML VOLUME OF PLASMA WAS MIXED WITH 2.5 ML 60% METHANOL AQUEOUS SOLUTION, AND CENTRIFUGED AT 1100 G FOR 10 MIN. THE SEPERNATANT FLUID WAS FURTHER PURIFIED BY SPE WITH 200 MG/5 ML 40 MICRONS OCTADECYL SILICA AND SEPARATION WAS OBTAINED USING A REVERSED-PHASE COLUMN UNDER ISOCRATIC CONDTIONS WITH ULTRAVIOLET ABSORBANCE DETECTION. THE INTRA- AND INTER-DAY PRECISION, DETERMINED AS RELATIVE STANDARD DEVIATIONS, WERE LESS THAN 5.0%, AND METHOD RECOVERY WAS MORE THAN 97%. THE LOWER LIMIT OF QUANTITATION, BASED ON STANDARDS WITH ACCEPTABLE RSDS, WAS 2.5 NG/ML. NO ENDOGENOUS COMPOUNDS WERWE FOUND OT INTERFERE WITH ANALYSIS. A GOOD LINEAR RELATIONSHIP WITH A REGRESSION COEFFICIENT OF 0.9999 IN THE RANGE OF 2.5 TO 200 NG/ML WAS OBSERVED. THIS METHOD HAS BEEN DEMONSTRATED TO BE SUITABLE FOR PHARMACOKINEIC STUDIES IN HUMANS. |
| Dose amount | VAR |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |