Experiment 635441
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Aesculus hippocastanum (HIPPOCASTANACEAE) |
| Citation | BISLER,H: PFEIFER,R: KLUKEN,N: PAUSCHINGER,P:. (1986). EFFECT OF HORSE-CHESTNUT SEED EXTRACT ON TRANSCAPILLARY FILTRATION IN CHRONIC VENOUS INSUFFICIENCY.. 111() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECT OF HORSE-CHESTNUT SEED EXTRACT (STANDARDIZED ON AESCIN; VENOSTASIN RETARD) WAS ASSESSED IN A RANDOMIZED PLACEBO-CONTROLLED CROSSOVER DOUBLE-BLIND TRIAL OF 22 PATIENTS WITH PROVEN CHRONIC VENOUS INSUFFICENCY BY MEASURING THE CAPILLARY FILTRATION COEFFICIENT AND THE INTRAVASCULAR VOLUME OF THE LOWER LEG BY VENOUS-OCCLUSION PLETHYSMOGRAPHY. 3 HOURS AFTER TAKING 2 CAPSULES OF VENOSTASIN (600 MG; EACH CAPSULE CONTAINING 50 MG AESCIN) THE CAPILLARY FILTRATION COEFFICIENT HAD DECREASED BY 22%, WHEREAS AFTER ADMINISTRATION OF AN IDENTICAL-LOOKING PLACEBO CAPSULE IT ROSE BUT SLIGHTLY OVER 3 HOURS. THE DIFFERENCE IN THE EFFECT OF VENOSTASIN AND PLACEBO IS STATISTICALLY SIGNIFICANT(P=0.006). THE INTRAVASCULAR VOLUME WAS REDUCED 5% MORE AFTER VENOSTASIN THAN THE PLACEBO, BUT THIS IS NOT STATISTICALLY SIGNIFICANT. IT IS CONCLUDED THAT VENOSTASIN HAS AN INHIBITORY EFFECT ON OEDEMA FORMATION VIA A DECREASE IN TRANSCAPILLARY FILTRATION AND THUS IMPROVES OEDEMA- RELATED SYMPTOMS IN VENOUS DISEASES OF THE LEG. A COMMERCIAL PRODUCT, VENOSTATIN, WAS USED. |
| Dose amount | 1.20 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |