Experiment 635748
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | WEITMAN,S: LANGEVIN,AM: BERKOW,RL: THOMAS,PJ: HURWITZ,CA: KRAFT,AS: DUBOWY,RL: SMITH,DL: BERNSTEIN,M:. (1999). A PHASE I TRAIL OF BRYOSTATIN-1 IN CHILDREN WITH REFRACTORY SOLID TUMORS: A PEDIATRIC ONCOLOGY GROUP STUDY.. 5(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | TWENTY-TWO PATIENTS ON FIVE DOSE LEVELS WERE EVALUABLE FOR TOXICIITES. AT THE 57 MCG/M2/DOSE LEVEL DOSE-LIMITING MYALGIA (GRAD 3) WAS OBSERVED IN THREE PATIENTS; TWO OF THOSE PATIENTS ALSO EXPERIENCED PHOTOPHOBIA OR EYE PAIN, AND ONE EXPERIENCED HEADACHE. SYMPTOMS OCCURRED IN ALL PATIENTS WITHIN 24-72 HRS AFTER THE SECOND DOSE OF BRYOSTATIN-1 WITH RESOLUTION WITHIN 1 WEEK OF ONSET. OTHER OBSERVED TOXICITIES (GRADES 1 AND 2) INCLUCED ELEVATION IN LIVER TRANSAMINASES, THROMBOCYTOPENIA, FEVER, AND FLU-LIKE SYMPTOMS THE BRYOSTATIN-1 INFUSION WAS TYPICALLY WELL TOLERATED. ALTHOUGH STABLE DISEASE WAS NOTED IN SEVERAL PATIENTS, ONLY COMPLETED OR PARTIAL RESPONSES WERE OBSERVED. |
| Dose amount | 57.0 MCG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN CHILD |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |