Experiment 635749
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | WEITMAN,S: LANGEVIN,AM: BERKOW,RL: THOMAS,PJ: HURWITZ,CA: KRAFT,AS: DUBOWY,RL: SMITH,DL: BERNSTEIN,M:. (1999). A PHASE I TRAIL OF BRYOSTATIN-1 IN CHILDREN WITH REFRACTORY SOLID TUMORS: A PEDIATRIC ONCOLOGY GROUP STUDY.. 5(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE PEDIATRIC ONCOLOGY GROUP EVALUATED THE CLINICLA TOXICITIES AND PHARMACOKINETICS OF BRYOSTATIN-1 GIVEN AS A 1-H INFUSION WEEKLY FOR 3 OF 4 WEEKS TO CHILDREN WITH REFRACTORY SOLID TUMORS. MYALGIA, PHOTOPHOBIA OR EYE PAIN, AND HEADACHE WERE DOSE LIMITING AT THE 57 MCG/M2/DOSE. THE DLTS OBSERVED IN THE RECOMMENDED PHASE II DOSE OF BRYOSTATIN-1 ADMINISTERED AS A 1-H INFUSION WEEKLY FOR 3 OF EVERY 4 WEEKS TO CHILDREN WITH SOLID TUMORS IN 44 MCG/M2/DOSE. MYALGIA, PHOTOPHOBIA, OR EYE PAIN, AS WELL AS HEADACHE, WERE FOUND TO BE DOSE LIMITING. |
| Dose amount | 44.0 MCG |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | HUMAN CHILD |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |