Experiment 636857

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismPteridium aquilinum (DENNSTAEDTIACEAE)
CitationBROWN,LM: ZAZHM,SH: HOOVBER,RN: FRAUMENT,J:. (1999). BRACKEN FERN CONSUMPTION AND HUMAN BLADDER CANCER.. 53(10)
Amount utilized
Compound isolated
DiseaseTHE STUDY INCLUDED ALL WHITE RESIDENTS OF VERMONT AND NEW HAMPSHIRE WHO DIED DURING 1975-79 FROM BLADDER CANCER. TWO RANDOMLY SELECTED CONTROLS PER CASE, MARCHED ON STATE, GENDER, RACE, AGE(+/2 YEARS) AND YEAR OF DEATH, WERE RANDOMLY SELECTED FROM ALL OTHER RESIDENT DEATHS (EXCLUDING SUICIDES). A QUESTIONNAIRE SOUGHT INFORMATION ON DEMOGRAPHIC CHARACTERISTICS, LIFETIME OCCUPATIONAL AND RESIDENTIAL HISTORIES, HISTORY INCLUDING BLADDER INFECTION, AND CONSUMPTION OF SELECTED DIETARY ITEMS INCLUDING BRACKEN FERN (FIDDLEHEAD GREENS). INTERVIEWS WERE CONDUCTED WITH THE NEXT OF KIN OF 325 CASES AND 673 CONTROLS. ODDS RATIOS (OR) WERE CALCULATED USING BOTH CONDITIONAL AND UNCONDITIONAL LOGISTIC REGRESSION. AS BOTH METHODS YIELDED SIMILAR RESULTS, THE UNCONDITIONAL RESULTS WERE PRESENTED. A TOTAL OF 24 CASES (7.4%) AND 71 CONTROLS (10.6%) WERE REPORTED TO HAVE EVER EATEN BRACKEN FERN (OR=0.6, 95% CONFIDENCE INTERVALS (CI)=0.4, 1.0). REGULAR CONSUMPTION OF BRACKEN FERN WAS REPORTED FOR 15 CASES (4.6%) AND 38 CONTROLS (5.6%), OR=0.8 (CI=0.4, 1.4). OUR NEGATIVE FINDINGS ARE CONSISTENT WITH A CANADIAN POPULATION-BASED CASE-CONTROL STUDY OF 480 MALE AND 152 FEMALE CASE-CONTROL PAIRS THAT SHOWED NO EXCESS BLADDER CANCER RISK ASSOCIATED WITH CONSUMPTION OF FIDDLEHEAD GREENS.
Number1
Qualitative resultINACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractTYPE EXT NOT STATED
GenderGIVEN TO BOTH SEXES