Experiment 636860
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Vitis vinifera (VITACEAE) |
| Citation | HARMAND,MF: BLANQUET,P:. (1978). THE FATE OF TOTAL FLAVANOLIC OLIGOMERS (OFT) EXTRACTED FROM "VITIS VINIFERA L." IN THE RAT.. 1978(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE ELIMINATION, METABOLISM AND DISTRIBUTION OF 14C-TOTAL FLAVANOLIC OLIGOMERS (OFT), VITAMIN P FACTORS EXTRACTED FROM "VITIS VINIFERA", IS DISCRIBED, IN THE RAT, AS A FUNCTION OF TIME. AFTER A SINGLE ORAL ADMINISTRATION OF 50 MG/KG [U-14C] OFT, ABOUT 70% OF THE ADMINISTERED DOSE IS ELIMINATED IN THE FIRST 24 HOURS: 6% OF THE DOSE IS EXCRETED AS 14CO2 IN EXPIRED AIR, 19% IS ELIMINATED IN URINE AND 45% IN FAECES. THE MAJOR URINARY METABOLITS ARE HIPPURIC ACID, ETHYLCATECHOL AND M- HYDROXYPHENYLPROPIONIC ACID. THE MAJOR FAECAL METABOLITE IS ETHYLACATECHOL. THE MAJOR BILIARY METABOLITES ARE VANILLIC ACID AND M-HYDROXYPHENYLPROPIONIC ACID. THE DEGRADATION OF OFT IS DEPENDENT ON THE ACTIVITY OF THE MICROFLORA IN THE GUT. THE DISTRIBUTION OF RADIOACTIVITY IN RAT TISSUES SHOWS THAT THERE ARE TWO KINDS OF TARGET TISSUES OF OFT: CONNECTIVE TISSUES AND TISSUES OF THE ADRENAL-THYROID-PITUITARY AXIS. |
| Dose amount | 50.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | FLAVONOID FRACTION |
| Gender | MALE |