Experiment 636864
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | JOSEY,ES: TACKETT,RL:. (1999). ST.JOHN'S WORT: A NEW ALTERNATIVE FOR DEPRESSION?. 37(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | A DOUBLE-BLIND STUDY (FOUR WEEKS IN LENGTH) WAS PERFORMED TO MEASURE THE EFECTIVENESS OF HYPERICUM AS COMPARED TO THE TRICYCLIC ANTIDEPRESSANT, MAPROTILINE. NO SIGNIFICANT DIFFERENCES WERE SEEN IN THE EFFICACY OF THE TWO GROUPS. THIS STUDY DOES, HOWEVER, CONCLUDE THAT HYPERICUM IS AS EFFECTIVE AS MAPROTILINE AS AN ANTIDEPRESSANT. THE SIDE-EFFECT PROFILE APPEARED TO BE LESS EXTENSIVE WITH THE HYPERICUM THERAPY. 25% (13/51) OF PATIENTS ON HYPERICUM THERAPY. THE MAJORITY OF THESE SIDE- EFFECTS INVOLVED FATIGUE (SEEN IN ONLY 2 PATIENTS ON HYPERICUM VERSUS 11 PATIENTS ON MAPROTILINE), DIZZINESS, DRY MOUTH, AND GASTRIONTESTINAL SYMPTOMS. UNSPECIFIC HEART COMPLAINTS WERE REPORTED IN THE MAPROTILINE-TREATED PATIENTS BUT NOT IN THOSE ON HYPERICUM THERAPY. IN ADDITION, FEWER PATIENTS DISCONTINUED THE STUDY WHILE TAKING HYPERICUM THAN DID THOSE IN THE MAPROTILINE-TREATED GROUP (6.9% VERSUS 8.8%). A COMMERCIAL PRODUCT, JARSIN 300, WAS USED. |
| Dose amount | 900.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |