Experiment 636874
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | WAGNER,J: WAGNER,ML: HENING,WA:. (1998). BEYOND BENZODIAZEPINES: ALTERNATIVE PHARMACOLOGIC AGENTS FOR THE TREATMENT OF INSOMNIA.. 32(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | INVESTIGATION INVOLVING HEALTHY MEN YIELDED NO SUBJECTIVE CHANGES IN SLEEP AFTER SINGLE DOSES OF MELATONIN 1 OR 5 MG WERE TAKEN AT 2245. AN INCREASE IN REM LATENCY WITH THE 5-MG DOSE WAS THE ONLY POLYSOOMNOGRAPHIC CHANGE NOTED. SUBJECTS SLEEPING LESS THAN 4 HOURS PER NIGHT FOR THE PREVIOUS 6 MONTHS REPORTED THAT MELATONIN 1 OR 5 MG GIVEN 15 MINUTES BEFORE BEDTIME IMPROVED SLEEP QUALITY, ALTHOUGH THERE WERE NO OTHER IMPROVEMENTS IN SLEEP PARAMETERS. POLYSOMNOGRAPHY DEMONSTRATED AN INCREASE IN REM LATENCY WITH THE 1-MG DOSE. |
| Dose amount | 5.0 MG |
| Number | 7 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | MALE |