Experiment 636888
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | GAMBARANA,C: GHIGLIERI,O: TOLU,P: DE MONTIS,MG: GIACHETTI,D: BOMBARDELLI,E: TAGLIAMONTE,A:. (1999). EFFICACY OF AN HYPERICUM PERFORATUM (ST.JOHN'S WORT) EXTRACT IN PREVENTING AND REVERTING A CONDITION OF ESCAPE DEFICIT IN RATS.. 21(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECTS OF H.PERFORATUM WERE STUDIED ON THREE ANIMAL MODELS OF DEPRESSION:(I) AN ACUTE FORM OF ESCAPE DEFICIT (ED) INDUCED BY AN UNAVOIDABLE STRESS; (II) A CHRONIC MODEL OF ED, WHICH CAN BE MAINTAINED BY THE ADMINSITRATION OF MILD STRESSORS ON ALTERNATE DAYS; (III) A MODEL OF ANHEDONIA BASED ON THE FINDING THAT REPEATED STRESSORS PREVENT THE DEVELOPMENT OF AN APPETITIVE BEHAVIOR INDUCED BY VANILLA SUGAR IN SATIATED RATS FED AD LIBITUM. H.PERFORATUM ACUTELY PROTECTED ANIMALS FROM THE SEQUELAE OF UNAVOIDABLE STRESS; SUCH AN EFFECT WAS PARTIALLY PREVENTED BY THE ADMINISTRATION OF SCH 23390 OR (-)-PINDOLOL. MOREOVER, H.PERFORATUM REVERTED THE ED MAINTAINED BY REPEATED STRESSORS AND PRESERVED THE ANIMAL'S CAPACITY TO LEARN TO OPERATE FOR EARNING A POSITIVE REINFORCER. |
| Dose amount | 1.5 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | MALE |