Experiment 637422
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Allium sativum (LILIACEAE) |
| Citation | BORDIA,A: SHARMA,KD: PARMAR,YK: VERMA,SK:. (1982). PROTECTIVE EFFECT OF GARLIC OIL ON THE CHANGES PRODUCED BY 3 WEEKS OF FATTY DIET ON SERUM CHOLESTEROL, SERUM TRIGLYCERIDES, FIBRINOLYTIC ACTIVITY AND PLATELET ADHESIVENESS IN MAN.. 34(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | 40 HEALTHY INDIVIDUALS WERE DIVIDED INTO GROUPS OF 20 EACH. GROUP I WAS GIVEN 75 GM OF BUTTER ALONG WITH THEIR USUAL DAILY DIET WHILE GROUP II WAS FED, IN ADDITIONAL TO BUTTER, GARLIC OIL (0.25 MG/KG BODY WEIGHT) IN TWO DIVIDED DOSES. THREE WEEKS OF FAT ADMINISTRATION RAISED SERUM CHOLESTEROL BY 10.3% IN GROUP I WHICH WAS NOT SIGNIFICANT, WHILE THE RISE WAS ONLY 3.2% IN GROUP II INDIVIDUALS. ON THE OTHER HAND SERUM TRIGLYCERIDES INCREASED SIGNIFICANTLY WHEN ONLY FAT WAS ADMINISTERED, THIS RISE WAS DISTINCTLY INHIBITED WHEN GARLIC WAS ADDED. A FALL IN FIBRINOLYTIC ACTIVITY (FA) BY 22.6% WAS OBSERVED AT THE END OF 3 WEEKS OF FATTY DIET. GARLIC NOT ONLY PREVENTED THIS FALL BUT ACTUALLY INCREASED THE FA BY 36.3% ABOVE THE INITIAL LEVELS. SIMILARLY PLATELET ADHESIVE INDEX (PAI) INCREASED BY 30% WITH THE FATTY MEAL WHILE THIS WAS REDUCED BY 16% BELOW THE INITIAL LEVELS WHERE GARLIC WAS ADDED. |
| Dose amount | 0.50 MG |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | ETOAC EXT |