Experiment 637532
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | PACKER,L: RIMBACH,G: VIRGILI,F:. (1999). ANTIOXIDANT ACTIVITY AND BIOLOGIC PROPERTIES OF A PROCYANIDIN-RICH EXTRACT FROM PINE (PINUS MARITIMA) BARK, PYCNOGENOL.. 37(5/6) |
| Amount utilized | |
| Compound isolated | |
| Disease | MODULATION OF MACROPHAGE ACTIVITY. WERHAVE RECENTLY DEMONSTRATED THAT PYC SIGNIFICANTLY AFFECTS INOS EXPRESSION AND ACTIVITY IN MURINE MACROPHAGES (RAW 264.7 CELL LINE) ACTIVATED BY LPS AND IFN-GAMMA [40]. THE BIPHASIC EFFECT ON INOS ACTIVITY OBSERVED IN VITRO WAS CONFIRMED IN CULTURED MOUSE MACROPHAGE CELLS AFTER PREINCUBATION WITH PYC AND SUBSEQUENT ACTIVATION WITH LPS AND IFN-GAMMA, A SIMILAR BIPHASIC MODULATION OF THE GENERATION OF NO2- AND NO3- HAS ALSO BEEN OBSERVED. |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Dose expression | CONC USED |