Experiment 637534
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | PACKER,L: RIMBACH,G: VIRGILI,F:. (1999). ANTIOXIDANT ACTIVITY AND BIOLOGIC PROPERTIES OF A PROCYANIDIN-RICH EXTRACT FROM PINE (PINUS MARITIMA) BARK, PYCNOGENOL.. 37(5/6) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN PROCYANIDINS BOUND TO INSOLUBLE ELASTINE IN A QUASI SPECIFIC FASHION, SIGNIFICANTLY AFFECTING ITS RATE OF DEGRADATION BY EITHER PURIFIED PORCINE PANCREATIC ELASTASE OR HUMAN LEUKOCYTE ELASTASE. THE AUTHORS SUGGEST THAT THE MECHANISM FOR THE INHIBITION OF ELASTINE CLEAVAGE WAS THE BINDING OF PROCYANIDINS TO PROLINE RESIDUES, WHICH IN TURN INCREASES THE NON NPRODUCTIVE (E.E., NOENZYMATICALLY ACTIVE) BINDING OF ELASTASE TO THE SUBSTRATE. |
| Number | 6 |
| Qualitative result | ACTIVE |
| Animal | PIG |
| Dose expression | CONC USED |