Experiment 637540
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | PACKER,L: RIMBACH,G: VIRGILI,F:. (1999). ANTIOXIDANT ACTIVITY AND BIOLOGIC PROPERTIES OF A PROCYANIDIN-RICH EXTRACT FROM PINE (PINUS MARITIMA) BARK, PYCNOGENOL.. 37(5/6) |
| Amount utilized | |
| Compound isolated | |
| Disease | TELOMERASE INHIBITION AND TELOMERE SHORTENING BY FLAVONOIDS WAS RECENTLY INVESTIGATED. THE PRESENCE OF CATECHIN DERIVATIVES RESULTED IN LIFE-SPAN REDUCTION OF MONOBLASTOID LEUKEMIA AND COLON ADENOCARCINOMA CELLS ACCOMPANIED BY TELOMER SHORTENING CHROMOSOMAL ABNORMALITIES, AND EXPARESSION OF SENESCENCE-ASSOCIATED BETA-GALACTOSIDASE. TELOMERASE IS KNOWN TO BE A KEY ENZYME ESSENTIAL FOR UNLOCKING THE PROLIFERATIVE CAPACITY OF CANCER BY MAINTAINING THE TIPS OF THE CHROMOSOMES, AND IT HAS BEEN PROPOSED TO BE MODULATED BY OXIDATIVE STRESS. |
| Number | 12 |
| Qualitative result | ACTIVE |
| Animal | SPECIES NOT STATED |
| Dose expression | CONC USED |