| Disease | THE EFFECTS OF ISOFLAVONE CONSUMPTION IN 14 PREMENOPAUSAL WOMEN WERE STUDIED, ISOFLAVONES WERE CONSUMED IN SOY PROTEIN POWDERS AND PROVIDED RELATIVE TO BODY WEIGHT (CONTROL DIET, 10 +/- 1.1; LOW ISOFLAVONE DIET, 64 +/- 9.2; HIGH ISOFLAVONE DIET,
128 +/- 16 MG/DAY) FOR 3 MENSTRUAL CYCLES PLUS 9 DAYS IN A RANDOMIZED CROSS-OVER DESIGN. DURING THE LAST 6 WEEKS OF EACH DIET PERIOD, PLASMA WAS COLLECTED EVERY OTHER DAY FOR ANALYSIS OF ESTROGENS, PROGESTERONE, LH, AND FSH, DIET EFFECTS WERE
ASSESSED DURING EACH OF FOUR DISTINCTLY DEFINED MENSTRUAL CYCLE PHASES. PLASMA FROM THE EARLY FOLLICULAR PHASE WAS ANALYZED FOR ANDROGENS, CORTISOL, THYROID HORMONES, INSULIN, PRL, AND SEX HORMONE-BINDING GLOBULIN. THE LOW ISOFLAVONE DIET
DECREASED LH(P= 0.009) AND FSH(P= 0.04) LEVELS DURING THE PERIOVULATORY PHASE. THE HIGH ISOFLAVONE DIET DECREASED FREE T-3(P= 0.02) AND DEHYDROEPIANDROSTERONE SULFATE (P= 0.02) LEVELS DURING THE EARLY FOLLICULAR PHASE AND ESTRONE LEVELS DURING
THE MIDFOLLICULAR PHASE (P= 0.02). NO OTHER SIGNIFICANT CHANGES WERE OBSERVED IN HORMONE CONCENTRATIONS OR IN THE LENGTH OF THE MENSTRUAL CYCLE, FOLLICULAR PHASE, OR LUTEAL PHASE. ENDOMETRIAL BIOPSIES PERFORMED IN THE LUTEAL PHASE OF CYCLE 3 OF
EACH DIET PERIOD REVEALED NO EFFECT OF ISOFLAVONE CONSUMPTION ON HISTOLOGICAL DATING. THESE DATE SUGGEST THAT EFFECTS ON PLASMA HORMONES AND THE MENSTRUAL CYCLE ARE NOT LIKELY TO BE THE PRIMARY MECHANISMS BY WHICH ISOFLAVONES MAY PREVENT CANCER
IN PREMENOPAUSAL WOMEN. LOW ISOFLAVONE DIET. |