Experiment 637566
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | RIGNEY,U: KIMBER,S: HINDMARCH,I:. (1999). THE EFFECTS OF ACUTE DOSES OF STANDARDIZED GINKGO BILOBA EXTRACT ON MEMORY AND PSYCHOMOTOR PERFORMANCE IN VOLUNTEERS.. 13(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS STUDY INVESTIGATED THE EFFECTS OF ACUTE DOSES OF GINKGO BILOBA EXTRACT (GBE) ON MEMORY AND PSYCHOMOTOR PERFORMANCE IN A RANDOMIZED, DOUBLE-BLIND AND PLACEBO CONTROLLED 5-WAY CROSS-OVER DESIGN. 31 VOLUNTEERS AGED 30-59 YEARS RECEIVED GBE 150 MG(50 MG T.D.D), GBE 300 MG(100 MG T.D.S.), GBE 12 MG MANE AND GBE 240 MG MANE AND PLACEBO FOR 2 DAYS. FOLLOWING BASELINE MEASURES, THE MEDICATION WAS ADMINISTERED AT 0900 H FOR THE SINGLE DOSES AND AT 0900, 1500 AND 2100 H FOR THE MULTIPLE DOSES. ATHE PSYCHOMETRIC TEST BATTERY WAS ADMINISTERED PARE-DOSE(0830 H) AND THEN AT FREQUENT INTERVALS UNTIL 11 H POST DOSE. THE RESULTS CONFIRM THAT THE EFFECTS OF GBE EXTRACT ON ASPECTS OF COGNITION IN ASYMPTOMATIC VOLUNTEERS ARE MORE PRONOUNCED FOR MEMORY, PARTICULARLY WORKING MEMORY. THEY ALSO SHOW THAT THESE EFFECTS MAY BE DOSE DEPENDENT THOUGH NOT IN A LINEAR DOSE RELATED MANNER, AND THAT GBE 120 MG PRODUCES THE MOST EVIDENT EFFECTS OF THE DOSES EXAMINED. ADDITIONALLY, THE RESULTS SUGGEST THAT THE COGNITIVE ENHANCING EFFECTS OF GBE ARE MORE LIKELY TO BE APPARENT IN INDIVIDUALS AGED 50-59 YEARS. |
| Dose amount | 240.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(100%)EXT |
| Gender | GIVEN TO BOTH SEXES |