| Disease | IN A CONTROLLED EXPERIMENT, THE SIGNIFICANCE OF AN INTERACTION BETWEEN CIPROFLOXACIN AND SANGUISORBA OFFICINALIS L.(SO), A MINERAL-RICH HERBAL MEDICINE, WAS EVALUATED IN THIS STUDY. MALE SPRAGUE-DAWLEY RATS(220-250 G) RECEIVING CIPROFLOXACIN
DOSAGES OF 20 MG/KG PO WERE CONCOMITANTLY DOSED WITH AN AQUEOUS EXTRACT OF SO(EQUIVALENT TO 2 G/KG CRUDE DRUG). BLOOD AND URINE SAMPLES WERE COLLECTED OVER 6 AND 24 H, RESPECTIVELY, FOR THE QUANTITATION OF CIPROFLOXACIN BY HPLC. THE PRESENCE OF
SO REDUCED SIGNIFICANTLY(P < 0.05) THE MAXIMUM PLASMA CONCENTRATION, THE AREA UNDER THE CONCENTRATION-TIME CURVE AND THE URINARY RECOVERY OF CIPROFLOXACIN, BY 94%, 78% AND 79%, RESPECTIVELY, COMPARED WITH RATS RECEIVING ONLY CIPROFLOXACIN. THE
PRESENCE OF SO ALSO CAUSED AN EIGHT-FOLD AND TWO-FOLD INCREASE IN DRUG DISTRIBUTION(VD,IZ/F) AND TERMINAL ELIMINATION HALF-LIFE(T1/2,IZ) FROM 30.8L/KG AND 1.96 H, RESPECTIVELY. THEREFORE, SHOULD THE USE OF BOTH AGENTS BE REQUIRED, SUFFICIENT
TIME SHOULD BE ALLOWED TO ENSURE THE EFFICACY OF CIPROFLOXACIN. |