Experiment 637574
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | WALUGA,M: JANUSZ,M: KARPEL,E: HARTLEB,M: NOWAK,A:. (1998). CARDIOVASCULAR EFFECTS OF EPHEDRINE, CAFFEINE AND YOHIMBINE MEASURED BY THORACIC ELECTRICAL BIOIMPEDANCE IN OBESE WOMEN.. 18(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | THREE GROUPS OF SUBJECTS WERE STUDIED: (1) NINE OBESE WOMEN RECEIVING ONLY A STANDARD HYPOCALORIC DIET; (2) NINE OBESE WOMEN RECEIVING A STANDARD HYPOCALORIC DIET AND EPHEDRINE (2X25 MG) WITH CAFFEINE (2X200 MG); (3) NINE OBESE WOMEN RECEIVING A STANDARD HYPOCALORIC DIET AND EPHEDRINE (2X25 MG) WITH CAFFEINE (2X200 MG) AND YOHIMBINE (2X5 MG). THE CARDIOVASCULAR STATE WAS EVALUATED BY THORACIC ELECTRICAL BIOIMPEDANCE, AUTOMATIC SPHYGMOMANOMETRY AND CONTINUOUS ECG RECORDING. IN EACH PATIENT, THE HEMODYNAMIC STUDY WAS PERFORMED TWICE: AT REST, I.E. BEFORE TREATMENT; AND AFTER 10 DAYS OF TREATMENT. ON THE SAME DAYS IN EACH PATIENT, THE HEMODYNAMIC TESTS WERE PERFORMED DURING PHYSICAL EXERCISES (HANDGRIP STRESS AND CYCLOERGOMETER EXERCISE). CAFFEINE AND EPHEDRINE HAD NO HEMODYNAMIC EFFECT IN RESTING PATENTS. THESE TWO DRUGS LED TO AN INCREASE IN EJECTION FRACTION DURING CYCLOERGOMETER EXERCISE. PHARMACOLOGICAL SUPPLEMENT OF EPHEDRINE AND CAFFEINE TO A LOW CALORIC DIET MODIFIED THE CARDIOVASCULAR SYSTEM WEAKLY, BUT THE ADDITION OF YOHIMBINE TO THIS REGIMEN ATTENUATED CARDIAC PERFORMANCE DURING REST AND HANDGRIP AND INCREASED CARDIAC WORK DURING DYNAMIC EXERCISE. |
| Dose amount | 400.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | FEMALE |