Experiment 637580
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Plantago ovata (PLANTAGINACEAE) |
| Citation | ANDERSON,JW: ALLGOOD,LD: TURNER,J: OELTGEN,PR: DAGGY,BP:. (1999). EFFECTS OF PSYLLIUM ON GLUCOSE AND SERUM LIPID RESPONSES IN MEN WITH TYPE 2 DIABETES AND HYPERCHOLESTEROLEMIA.. 70(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | AFTER A 2-WK DIETARY STABILIZATION PHASE, 34 MEN WITH TYPE 2 DIABETES AND MILD-T0-MODERATE HYPERCHOLESTEROLEMIA WERE RANDOMLY ASSIGNED TO RECEIVE 5.1 G PSYLLIUM OR CELLULOSE PLACEBO TWICE DAILY FOR 8 WKS. SERUM LIPID AND GLYCEMIC INDEXES WERE EVALUATED BIWEEKLY ON AN OUTPATIENT BASIS AND AT WEEKS 0 AND 8 IN A METABOLIC WARD. IN THE METABOLIC WARD, THE PSYLLIUM GROUP SHOWED SIGNIFICANT IMPROVEMENTS IN GLUCOSE AND LIPID VALUES COMPARED WITH THE PLACEBO GROUP. SERUM TOTAL AND LDL- CHOLESTEROL CONCENTRATIONS WERE 8.9% (P < 0.05) AND 13.0% (P = 0.07) LOWER, RESPECTIVELY, IN THE PSYLLIUM THAN IN THE PLACEBO GROUP. ALL-DAY AND POSTLUNCH POSTPRANDIAL GLUCOSE CONCENTRATIONS WERE 11.0% (P < 0.05) AND 19.2% (P < 0.01) LOWER IN THE PSYLLIUM THAN IN THE PLACEBO GROUP. BOTH PRODUCTS WERE WELL TOLERATED, WITH NO SERIOUS ADVERSE EVENTS RELATED TO TREATMENT REPORTED IN EITHER GROUP. THE ADDITION OF PSYLLIUM TO A TRADITIONAL DIET FOR PERSONS WITH DIABETES IS SAFE, IS WELL TOLERATED, AND IMPROVES GLYCEMIC AND LIPID CONTROL IN MEN WITH TYPE 2 DIABETES AND HYPERCHOLESTEROLEMIA. |
| Dose amount | 5.10 GM |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HUSKS |
| Gender | MALE |