Experiment 638820

Compounds isolated

Details

PropertyValue
Pharmacology
Administration routeINTRAGASTRIC
OrganismPanax ginseng (ARALIACEAE)
CitationWAKABAYASHI,C: HASEGAWA,H: MURATA,J: SAIKI,I:. (1997). IN VIVO ANTIMETASTATIC ACTION OF GINSENG PROTOPANAXADIOL SAPONINS IS BASED ON THEIR INTESTINAL BACTERIAL METABOLITES AFTER ORAL ADMINISTRATION.. 9(8)
Amount utilized
Compound isolated
DiseasePHARMACOKINETIC STUDIES OF GINSENOSIDE RB1 AND MI AFTER ORAL ADMINSITRATION (2 MG/MOUSE) REVEALED THAT INTACT RB1 WAS NOT DETECTABLE IN SERUM FOR 24 H BY HPLC ANALYSIS, WHEREAS THE LEVEL OF M1 IN THE SERUM REACHED MAXIMUM AT 8 H (8.5 + 0.4 UG/ ML) AFTER RB1 ADMINISTRATION AND AT 2 H (10.3 + 1.0 UG/ML) AFTER M1 ADMINISTRATION. THESE FINDINGS SUGGEST THAT THE VIVO ANTIMETASTIC EFFECT BY ORAL ADMINISTRATION OF GINSENOSIDES IS MEDIATED BY THEIR METABOLIC COMPONENT M1.
Dose amount0.5 MG
Number3
Qualitative resultACTIVE
AnimalMOUSE
Dose expressionDOSE
GenderFEMALE