Experiment 638996
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Urtica dioica (URTICACEAE) |
| Citation | LICHIUS,JJ: LENZ,C: LINDEMANN,P: MULLER,HH: AUMULLER,G: KONRAD,L:. (1999). ANTIPROLIFERATIVE EFFECT OF A POLYSACCHARIDE FRACTION OF A 20% METHANOLIC EXTRACT OF STINGING NETTLE ROOTS UPON EPITHELIAL CELLS OF THE HUMAN PROSTATE (LNCAP).. 54(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECTS OF DIFFERENT CONCENTRATIONS OF THE POLYSACCHARIDE FRACTION OF THE 20% METHANOLIC EXTRACT OF STINGING NETTLE ROOTS (POLY-M) ON THE CELLULAR PROLIFERATION OF LYMPH NODE CARCINOMA OF THE PROSTATE (LNCAP) CELLS WERE DETERMINED BY MEASUREMENT OF THE GENOMIC DNA CONTENT OF THE SAMPLES. ALL CONCENTRATIONS OF POLY-M SHOWED AN INHIBITORY EFFECT ON THE GROWTH OF THE LNCAP CELLS DURING 7 DAYS EXCEPT THE 2 LOWEST CONCENTRATION. THE REDUCED PROLIFERATION OF POLY-M TREATED LNCAP CELLS WAS SIGNIFICANTLY (P < 0.05) DIFFERENT FROM THE UNTREATED CONTROL. THE INHIBITION WAS TIME- AND CONCENTRATION-DEPENDENT WITH THE MAXIMUM SUPPRESSION (50%) ON DAY 6 AND AT CONCENTRATIONS OF 1.0E-9 AND 1.0E-11 MG/ML. NO CYTOTOXIC EFFECT OF POLY-M ON CELL PROLIFERATION WAS OBSERVED. THE IN VITRO RESULTS SHOW FOR THE FIRST TIME AN ANTIPROLIFERATIVE EFFECT OF URTICA COMPOUNDS ON HUMAN PROSTATIC EPITHELIUM. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CELL CULTURE |
| Dose expression | CONC USED |
| Extract | MEOH-H2O(1:5) |