Experiment 639011
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | ZI,XL: AGARWAL,R:. (1999). MODULATION OF MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION AND CELL CYCLE REGULATORS BY THE POTENT SKIN CANCER PREVENTIVE AGENT SILYMARIN.. 263(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | SILYMARIN TREATMENT OF CELLS RESULTED IN A SIGNIFICANT INHIBITION OF MITOGEN ACTIVATED PROTEIN KINASE (MAPK)/ERK1/2 ACTIVATION ONLY AT LOWER DOSES, WHEREAS HIGHER DOSES ACTIVATED MAPK/JNK1. THESE DIFFERENTIAL RESPONSES OF SILYMARIN WERE ACCOMPAINED BY ITS GROWTH INHIBITORY AND APOPTOTIC CELL DEATH EFFECTS AT LOW AND HIGH DOSES, RESPECTIVELY. SILYMARIN-CAUSED GROWTH INHIBITION WAS VIA BOTH G2-M AND G1 ARRESTS DUE TO A SIGNIFICANT DECREASE IN THE KINASE ACTIVITY AND PROTEIN LEVEL OF CDKS AND CYCLINS. DOSES OF SILYMARIN WERE FROM 10-150 MG/ML. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CELL CULTURE |
| Dose expression | DOSE |