Experiment 639034
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | VITIELLO,B:. (1999). HYPERICUM PERFORATUM EXTRACTS AS POTENTIAL ANTIDEPRESSANTS.. 51(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | A PLACEBO-CONTROLLED STUDY HAS TESTED THE EFFICACY OF TWO PREPARATIONS OF H.PERFORATUM THAT DIFFERED IN HYPERFORIN CONTENT. PATIENTS WITH DSM-IV-DEFINED MAJOR DEPRESSION WERE RANDOMLY ASSIGNED TO RECEIVE AN EXTRACT WITH 0.5% HYPERFORIN, ANOTHER EXTRACT WITH 5% HYPERFORIN, OR PLACEBO FOR 6 WEEKS. THE DECLINE OF THE HAMD SCORE WAS SIGNIFICANTLY GREATER IN THE GROUP ASSIGNED TO THE HIGH HYPERICIN EXTRACT THAN IN THE PLACEBO GROUP. THE DECLINE IN THE LOW HYPERICIN GROUP WAS NOT SIGNIFICANTLY DIFFERENT FROM THE DECLINE IN THE PLACEBO GROUP. BASED ON THE CGI IMPROVEMENT SCORE, THE RESPONSE RATE WAS 70% IN THE HIGH HYPERFORIN GROUP, 55% IN THE LOW HYPERFORIN GROUP, AND 48% IN THE PLACEBO GROUP. |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |