Experiment 639035
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | VITIELLO,B:. (1999). HYPERICUM PERFORATUM EXTRACTS AS POTENTIAL ANTIDEPRESSANTS.. 51(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | A STUDY COMPARED THE EFFICACY OF A COMMONLY USED H.PERFORATUM EXTRACT(LI 160) WITH AMITRIPTYLINE IN 156 PATIENTS WITH DSM-IV MAJOR DEPRESSION. THE H.PERFORATUM EXTRACT WAS GIVEN AT THE FIXED DOSE OF 300 MG 3 TIMES A DAY AND THE AMITRIPTYLINE DOSE WAS 25 MG 3 TIMES A DAY. THE DOUBLE-BLIND TRIAL LASTED 6 WEEKS. A PATIENTS WITH AT LEAST A 50% DECLINE FROM THE HAMILTON DEPRESSION RATING SCALE (HAMD) SCORE AT ENTRY, OR A FINAL SCORE BELOW 10, WAS JUDGED A RESPONDER. THE RESPONSE RATE WAS 60% IN THE HYPERICUM GROUP AND 78% IN THE AMITRIPTYLINE GROUP (P = 0.64). AT THE END OF THE STUDY, THE HAMD SCORE WAS LOWER (P < 0.05) IN THE AMITRIPTYLINE GROUP. |
| Dose amount | 900.0 MG |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |