Experiment 639036
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | VITIELLO,B:. (1999). HYPERICUM PERFORATUM EXTRACTS AS POTENTIAL ANTIDEPRESSANTS.. 51(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | 209 PATIENTS WITH MAJOR DEPRESSION (ICD-10 CRITERIA) WERE RANDOMIZED TO A 6-WEEK TRIAL OF LI160 (1800 MG PER DAY) OR IMIPRAMINE (75 MG PER DAY). THIS STUDY IS REMARKABLE FOR THE INCLUSION OF PATIENTS WITH MORE SEVERE SYMPTOMATOLOGY, AS EVIDENCED BY A MEAN HAND ENTRY SCORE OF ABOUT 25, AND FOR THE USE OF A HIGHER DOSE OF H.PERFORATUM. THE HAMD SCORES DECLINED IN BOTH GROUPS WITHOUT A STATISTICALLY SIGNIFICANT DIFFERENCE. THE IMPROVEMENT SCORE OF THE CLINICAL GLOBAL IMPRESSION (CGI), AS A SCALE COMMONLY USED TO DEFINE RESPONSE, SHOWED A TREND IN FAVOR OF IMIPRAMINE (P = 0.-79). THE RESPONSE RATE, USING THE CGI, WAS 61% IN THE H.PERFORATUM GROUP AND 71% IN THE IMIPRAMINE GROUP. A COMMERCIAL PRODUCT, HYPERIFORCE, WAS USED. |
| Dose amount | 1.8 GM |
| Number | 5 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |