Experiment 639115
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN RATION |
| Organism | Oenothera biennis (ONAGRACEAE) |
| Citation | TOMLINSON,DR: ROBINSON,JP: COMPTON,AM: KEEN,P:. (1989). ESSENTIAL FATTY ACID TREATMENT - EFFECTS ON NERVE CONDUCTION, POLYOL PATHWAY AND AXONAL TRANSPORT IN STREPTOZOTOCIN DIABETIC RATS.. 32() |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS STUDY WAS DESIGNED TO EXAMINE THE EFFECT OF DIETARY SUPPLEMENTATION WITH ESSENTIAL FATTY ACIDS (EVENING PRIMROSE OIL - 5% WEIGHT:WEIGHT ADDED TO THE DIET) ON ACUTE NEUROPHYSIOLOGICAL AND NEUROCHEMICAL DEFECTS IN STREPTOZOTOCIN-DIABETIC RATS. DIABETIC RATS, WHICH WERE NOT GIVEN EVENING PRIMROSE OIL, SHOWED HIGHLY SIGNIFICANT ELEVATIONS OF NERVE SORBITOL AND FRUCTOSE COMBINED WITH A DEPLETION OF NERVE MYO-INOSITOL. IN THOSE ANIMALS THERE WAS ALSO A 40% REDUCTION(P<0.02) IN THE ACCUMULATION OF AXONALLY TRASPORTED SUBSTANCE P-LIKE IMMUNOREACTIVITY PROXIMAL TO A 12 H SCIATIC NERVE LIGATURE TOGETHER WITH REDUCED MOTOR NERVE CONDUCTION VELOCITY (13%[P<0.001] AND 20%[P<0.001] IN TWO SEPERATE EXPERIMENTS. TREATMENT OF OTHER DIABETIC RATS WITH EVENING PRIMROSE OIL PREVENTED COMPLETELY THE DEVELOPMENT OF THE MOTOR NERVE CONDUCTION VELOCITY DEFICIT WITHOUT AFFECTING SORBITOL, FRUCTOSE OR MYO-INOSITOL LEVELS OR THE DEFICIT IN AXONAL TRANSPORT OR SUBSTANCE P. A COMMERCIAL PRODUCT, EFAMOL, WAS USED. |
| Dose amount | 5.0 % OF DIET |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | CONC USED |
| Extract | SEED OIL |
| Gender | MALE |