Experiment 639669
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Chelidonium majus (PAPAVERACEAE) |
| Citation | BENNINGER,J: SCHNEIDER,HT: SCHUPPAN,D: KIRCHNER,T: KAHN,KG:. (1999). ACUTE HEPATITIS INDUCED BY GREATER CELANDINE (CHELIDONIUM MAJUS).. 117(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | A REPORT OF 10 CASES OF ACUTE HEPATITIS INDUCED BY PREPARATIONS OF GREATER CELANDINE (CHELIDONIUM MAJUS), WHICH ARE FREQUENTLY PRESCRIBED TO TREAT GASTRIC AND BILIARY DISORDERS. THE COURSE OF HEPATITIS WAS MILD TO SEVERE. MARKED CHOLESTATSIS WAS OBSERVED IN 5 PATIENTS, BUT LIVER FAILURE DID NOT OCCUR. OTHER POSSIBLE CAUSES OF LIVER DISEASE (VIRAL, AUTOIMMUNE, HEREDITARY, ALCOHOL, AND SECONDARY BILIARY) WERE EXCLUDED BY LABORATORY TESTS AND IMAGING PROCEDURES, AND LIVER BIOPSY SPECIMENS WERE CONSISTENT WITH DRUG-INDUCED DAMAGE. AFTER DISCONTINUATION OF GREATER CELANDINE, RAPID RECOVERY WAS OBSERVED IN ALL PATIENTS AND LIVER ENZYME LEVELS RETURNED TO NORMAL IN 2-6 MONTHS. UNINTENTIONAL RECHALLENGE LED TO A SECOND FLARE TO HEPATIC INFLAMMATION IN 1 PATIENT. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | PLANT |
| Gender | FEMALE |