Experiment 639673
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INHALATION |
| Organism | Coprinus comatus (COPRINACEAE) |
| Citation | FISCHER,B: YAWALKAR,N: BRANDER KA: WERNER,JP: HELBLING,A:. (1999). COPRINUS COMATUS (SHAGGY CAP) IS A POTENIAL SOURCE OF AEROALLERGEN THAT MAY PROVOKE ATOPIC DERMATITIS.. 104(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | SIXTY-SIX SUBJECTS WERE CATEGORIZED IN GROUPS HAVING AD OR RESPIRATORY ALLERGY WITH REGARD TO THE SKIN PRICK TEST (SPT) REACTIVITY TO C COMATUS EXTRACT. TWENTY NONATOPIC INDIVIDUALS SERVED AS CONTROL SUBJECTS. ATOPY PATCH TESTS (APTS) WERE PERFORMED WITH EXTRACT OF C COMATUS SPORE CONTAINING TISSUE AT A CONCENTRATION OF 1.35 MG OF PROTEIN PER GRAM OF PETROLATUM (VASELINE) AND C COMATUS CAP AT A CONCENTRATION OF APPROXIMATELY 5 MG OF PROTEIN PER GRAM OF PETROLEUM JELLY. ATP REACTIONS WERE EVALUATED AFTER 48 AND 72 HOURS. OF THE SUBJECTS WITH AD COMPLETING THE STUDY, 12 (32%) OF 38 SHOWED A POSITIVE APT REACTION, WITH 8 (57%) ALSO HAVING A POSITIVE SPT RESPONSE TO C COMATUS. ONLY 1 (9%) OF 11 SUBJECTS WITH ASTHMA HAD A POSITIVE SPT AND APT RESPONSE TO C COMATUS. NO POSITIVE TEST REACTION WAS OBSERVED IN THE NONATOPIC CONTROL SUBJECTS OR IN SUBJECTS WITH RESPIRATORY ALLERGY AND NEGATIVE SPT RESPONSES TO C COMATUS. OUR RESULTS DEMONSTRATE THAT C COMATUS CAN INDUCED DELAYED-TYPE REACTIONS IN ATOPIC INDIVIDUALS, PARTICULARY IN THOSE WITH AD. BECAUSED SPORES OF C OPRINUS SPECIES ARE UBIQUITOUS, BASIDIOMYCETES HAVE TO BE CONSIDERED AS POSSIBLE AEROLLERGENS WHEN INVESTIGATING CAUSES OF ECZEMATOUS SKIN LESIONS IN AD. |
| Dose amount | 5.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | ML |
| Dose expression | CONC USED |
| Extract | SPORES |
| Gender | GIVEN TO BOTH SEXES |