Experiment 639679

Details

PropertyValue
Pharmacology
Administration routeINTRAGASTRIC
OrganismGinkgo biloba (GINKGOACEAE)
CitationDROY-LEFAIX,MT:. (1997). EFFECT OF THE ANTIOXIDANT ACTION OF GINKGO BILOBA EXTRACT (EGB 761) ON AGING AND OXIDATIVE STRESS.. 20()
Amount utilized
Compound isolated
DiseasePREVENTION OF AGE-ASSOCIATED OXIDATIVE STRESS IN MITOCHONDRIA(MT) WAS CONFIRMED MEASURING BY THE AMOUNT OF OXIDIZED BASE, 8 OXO-7-8 DIHYDRO 2'-DEOXYGUANOSINE (OXO 8 DG), AS A BIOMARKER OF OXIDATIVE DNA. IN BRAIN AND LIVER OF OLD RATS (27 MO) COMPARED TO YOUNG RATS (4 MO), THE OXIDATIVE DAMAGE TO MTDNA INCREASED WITH THE AGE. EGB 761 TREATMENT, GIVEN ORALLY AT THE DOSE OF 100 MG/KG DURING 3 MO BEFORE THE MTDNA EVALUAITON, SIGNIFICANTLY PREVENTED MTDNA DAMAGE. A COMMERCIAL PRODUCT, EGB-761, WAS USED.
Dose amount100.0 MG
Number5
Qualitative resultACTIVE
AnimalRAT
Per unitKG
Dose expressionDOSE
ExtractACETONE EXT