Experiment 639685
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ROUTE NOT GIVEN |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | DROY-LEFAIX,MT:. (1997). EFFECT OF THE ANTIOXIDANT ACTION OF GINKGO BILOBA EXTRACT (EGB 761) ON AGING AND OXIDATIVE STRESS.. 20() |
| Amount utilized | |
| Compound isolated | |
| Disease | IN ISCHEMIA-REPERFUSION, OXYGENATED FREE RADICALS MAY BE GENERATED BY SEVERAL PATHWAYS INCLUDING THE XANTHINE-OXIDASE SYSTEM (THE NADPH-DEPENDENT OXIDASE OF NEUTROPHILS), THE MITOCHONDRIA ELECTRON TRANSPORT CHAIN, AND ARACHIDONIC METABOLISM. TO VERIFY THE EFFECT OF THE ANTIOXIDANTS OF THE RETINA, EGB 761 WAS GIVEN 10 DAYS BEFORE THE EXPERIMENT TO ALBINO SPRAGUE-DAWLEY RATS. THE CENTRAL RETINAL ARTERY WAS OCCLUDED BY CLAMING 90 MIN, THEN REPERFUSION WAS PERMITTED AT 4-24 HR. THE RATS WERE THEN SACRIFIED AND THE RETINAS WERE RELEASED FOR ANALYSIS. IN UNTREATED RATS, HISTOLOGICAL RETINA ANALYSIS SHOWED DEGENERATIVE CHANGES WITH IMPORTANT EDEMA AND A NEUTROPHIL INVASION INTO THE DIFFERENT LAYERS OF THE RETINA. WITH EGB 761 PRETREAMENT, THE FREE RADICAL DETRIMENTAL EFFECTS WERE SIGNIFICANTLY REDUCED. A COMMERCIAL PRODUCT, EGB-761, WAS USED. |
| Number | 11 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |
| Extract | ACETONE EXT |