Experiment 642179
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | ZUTSHI,RK: SINGH,R: ZUTSHI,U: JOHRI,RK: ATAL,CK:. (1985). INFLUENCE OF PIPERINE ON RIFAMPICIN BLOOD LEVELS IN PATIENTS OF PULMONARY TUBERCULOSIS.. 33(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE INFLUENCE OF PIPERINE ON RIFAMPICIN LEVELS IN 14 PATIENTS(7 MALES, 7 FEMALES) OF PULMONARY TUBERCULOSIS WAS STUDIED. THE PATIENTS WERE FED 450 MG RIFAMPICIN AND BLOOD LEVELS OF THE DRUG DETERMINED BY UV SPECTROPHOTOMETER O.25, 0.5, 1,2,4,8 AND 12 HOURS LATER. AFTER FIVE DAYS RIFAMPICIN (450 MG) WAS COADMINISTERED WITH PIPERINE (50 MG) AND THE BLOOD LEVELS OF RIFAMPICIN WERE AGAIN MONITORED. A HIGHLY SIGNIFICANT(P< 0.01) INCREASE IN RIFAMPICIN PLASMA LEVELS AND AREA UNDER THE DRUG CONCENTRATION VERSUS TIME CURVE WAS NOTICED IN BOTH THE SEXES WHEN PIPERINE WAS COADMINISTERED, ALTHOUGH THERE WAS VARIATION IN THE T MAX. THE SEX DEPENDENT DIFFERENCE OBSERVED WAS STATISTICALLY INSIGNIFICANT. |
| Dose amount | 50.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |