Experiment 642203
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | AGARWAL,S: RAO,AV:. (1998). TOMATO LYCOPENE AND LOW DENSITY LIPOPROTEIN OXIDATION: A HUMAN DIETARY INTERVENTION STUDY.. 33(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED CROSS-OVER STUDY DESIGN WAS USED. ALL SUBJECTS COMPLETED ALL 4 TREATMENTS INCLUDING A PLACEBO, SPAGHETTI SAUCE(39.2MG LYCOPENE) TOMATO JUICE(50.4MG) AND TOMATOES IN CAPSULES(75.0MG) TEST PRODUCTS WERE CONSUMED AS A PART OF BREAKFAST TO STANDARDIZE THE DELIVERY OF LYCOPENE. BLOOD SAMPLES WERE COLLECTED AT THE END OF EACH TREATMENT.SERUM LYCOPENE WAS EXTRACTED AND MEASURED BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY USING AN ABSORBANCE DETECTOR. SERUM LDL WAS ISOLATED BY PRECIPITATION WITH BUFFERED HEPARIN, AND THIOBARBITURIC ACID-REACTIVE SUBSTANCES(TBARS) AND CONJUGATED DIENES(CD) WERE MEASURED TO ESTIMATE LDL OXIDATION. BOTH METHODS, TO MEASURE LDL OXIDATION LDL-TBARS AND LDL-CD, WERE IN GOOD AGREEMENT WITH EACH OTHER. DIETARY SUPPLEMENTATION OF LYCOPENE SIGNIFICANTLY INCREASED SERUM LYCOPENE LEVELS BY AT LEAST TWOFOLD. ALTHOUGH THERE WAS NO CHANGE IN SERUM CHOLESTEROL LEVELS(TOTAL, LDL, OR HIGH-DENSITY LIPOPROTEIN), SERUM LIPID PEROXIDATION AND LDL OXIDATION WERE SIGNIFICANTLY DECREASED. THESE RESULTS MAY HAVE RELEVANCE FOR DECREASING THE RISK FOR CORONARY HEART DISEASE. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |