Experiment 642206
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | HOLODNIV,M: KOCH,J: MISTAL,M: SCHMIDT,JM: KHANDWALA,A: PENNINGTON,JE: PORTER,SB:. (1999). A DOUBLE BLIND, RANDOMIZED, PLACEBO-CONTROLLED PHASE II STUDY TO ASSESS THE SAFETY AND EFICACY OF ORALLY ADMINISTERED SP-303 FOR THE SYMPTOMATIC TREATED OF DIARRHEA IN PATIENTS WITH AIDS.. 94(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | MULTICENTER PHASE II RANDOMIZED DOUBLE BLIND PLACEBO-CONTROLLED STUDY. HIV-POSITIVE SUBJECTS AND AIDS-DEFINING ILLNESS WERE ADMITTED TO AN INPATIENT STUDY UNIT. SUBJECTS RECIEVED 500 MG OF SP-303 OR PLACEBO EVERY 6 HOUR FOR 96 HOURS. STOOL FREQUENCY AND WEIGHTS WERE RECORDED. DAILY MEASURES ANALYSIS OVER 4 DAYS OF TREATMENT DEMONSTRATED THAT SP-303 SUBJECTS HAD A SIGNIFICANT REDUCTION IN STOOL WEIGHT AND ABNORMAL STOOL FREQUENCY WHEN COMPARED TO PLACEBO TREATED SUBJECTS. SP-303 IS SAFE AND WELL TOLERATED. SP-303 IS EFFECTIVE IN REDUCING STOOL WEIGHT AND FREQUENCY IN PATIENTS WITH AIDS AND DIARRHEA. |
| Dose amount | 2.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |