| Disease | IN A RANDOMIZED, 2-PHASE CROSSOVER STUDY, 10 HEALTHY VOLUNTEERS TOOK EITHER 200 ML DOUBLE-STRENGTH GRAPEFRUIT JUICE OR WATER 3 TIMES A DAY FOR 2 DAYS. ON DAY 3, EACH SUBJECT INGESTED 10 MG CISAPRIDE WITH EITHER 200 ML GRAPEFRUIT JUICE OR WATER,
AND AN ADDITIONAL 200 ML WAS INGESTED 1/2 HOUR AND 1 1/2 HOURS AFTER CISAPRIDE ADMINISTRATION. TIMED BLOOD SAMPLES WERE COLLECTED FOR 32 HOURS AFTER CISAPRIDE INTAKE, AND A STANDARD 12-LEAD ECG WAS RECORDED BEFORE THE ADMINISTRATION OF CISAPRIDE
AND 2,5,8, AND 12 HOURS LATER. THE MEAN PEAK PLASMA CONCENTRATION OF CISAPRIDE WAS INCREASED BY 81% (RANGE, 38% TO 138%; P<.01) AND THE TOTAL AREA UNDER THE PLASMA CISAPRIDE CONCENTRATIONB-TIME CURVE BY 144%(RANGE, 65% TO 244%; P<.01) BY
GRAPEFRUIT JUICE. THE TIME OF THE PEAK CONCENTRATION OF CISAPRIDE WAS PROLONGED FROM 1.5 TO 2.5 HOURS (P<.05) AND THE ELIMINATION HALF-LIFE FROM 6.8 TO 8.4 HOURS(P<.05) BY GRAPEFRUIT JUICE. ECG TRACINGS DID NOT SHOW ANY SIGNIFICANT DIFFERENCES
THE QTC INTERVAL BETWEEN THE GRAPEFRUIT JUICE AND CONTROL PHASES. GRAPEFRUIT JUICE SIGNIFICANTLY INCREASES PLASMA CONCENTRATIONS OF CISAPRIDE. |