Experiment 642952
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Paullinia cupana (SAPINDACEAE) |
| Citation | MARTINET,A: HOSTETMANN,K: SCHUTZ,Y:. (1999). THERMOGENIC EFFECTS OF COMMERCIALLY AVAILABLE PLANT PREPARATIONS AIMED AT TREATING HUMAN OBESITY.. 6(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | DIFFERENT COMMERCIALLY AVAILABLE PLANT PREPARATIONS HAVE BEEN CLAIMED TO HAVE ANTI-OBESITY ACTION. WE INVESTIGATED THE ACUTE EFFECTS OF ORAL ADMINISTRATION OF 12 OF THESE PREPARATIONS IN NON-OBESE WOMEN AND MEN. NO SIGNIFICANT INCREASE IN ENERGY EXPENDITURE (EE) HAS BEEN NOTED AFTER TREATMENT WITH ANY OF THESE PREPARATIONS. NO CHANGE IN RESPIRATORY QUOTIENT (RQ) WAS SHOWN, EXCEPT AFTER TREATMENT WITH MATE (ILEX PARAGUARIENSIS) EXTRACT, WHERE A DROP IN RQ WAS OBSERVED, INDICATING A RISE IN THE PROPORTION TO FAT OXIDIZED. THE RESULTS SUGGEST THE POOR POTENTIAL OF THESE PLANT PREPARATIONS IN THE TREATMENT OF OBESITY, EXCEPT POSSIBLY FOR THE MATE EXTRACT. A COMMERCIAL PRODUCT, CUPALINE, WAS USED. |
| Dose amount | 2.72 GM |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | SEEDS |
| Gender | GIVEN TO BOTH SEXES |