Experiment 64672
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | RAKIETEN,N: RAKIETEN,ML:. (1957). THE EFFECT OF L-MENTHOL ON THE SYSTEMIC BLOOD PRESSURE.. 46(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | L-MENTHOL IN PROPYLENE GLYCOL PRODUCES A FALL IN BLOOD PRESSURE OF CATS AND RABBITS WHEN ADMINISTERED I.V. IN DOSAGES OF 0.25 MG/KG. AND ABOVE. WHEN MIXTURES OF L-MENTHOL IN PROPYLENE GLYCOL AND NICOTINE ARE ADMINISTERED I.V. TO CATS AND RABBITS THE VASOCONSTRICTION PRODUCED BY NICOTINE IS BLOCKED COMPLETELEY WHEN THE RATIO OF MENTHOL TO NICOTINE IS 40 TO 80. THE DEGREE OF VASOCONSTRICTION IS DECREASED 10 TO 60 PER CENT WHEN THE RATIO OF MENTHOL TO NICOTINE IS 6 TO 20. |
| Dose amount | VAR |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | RABBIT |
| Dose expression | DOSE |