Experiment 647067
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | NGUYEN,TT: DALE,LC: VON BERGMANN,K: CROGHAN,IT:. (1998). CHOLESTEROL-LOWERING EFFECT OF STANOL ESTER IN A US POPULATION OF MILDLY HYPERCHOLESTEROLEMIC MEN AND WOMEN: A RANDOMIZED CONTROLLED TRIAL.. 74(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | AFTER A RUN-IN PHASE, 318 SUBJECTS WERE RANDOMIZED TO RECEIVE ONE OF THE FOLLOWING MARGARINE-LIKE SPREADS CONTAINING STANOL ESTER OR PLACEBO FOR 8 WEEKS: EU 3G: 1 G OF STANOL (ESTER FORM) PER 8-G SERVING OF A EUROPEAN FORMULA 3 TIMES A DAY; US 3 G: 1 G OF STANOL (ESTER FORM) PER 8-G SERVING OF A US REFORMULATION 3 TIMES A DAY; US 2 G: 0.067 G OF STANOL(ESTER FORM) PER 8-G SERVING OF A US REFORMULATION 3 TIMES A DAY; OR PLACEBO SPREAD. RESULTS: MEAN +/- SD BASELINE TOTAL CHOLESTEROL (TC) AND LOW-DENSITY LIPOPROTEIN CHOLESTEROL (LDL-C) LEVELS WERE 223+/-20 AND 153+/-21 MG/DL, RESPECTIVELY. IN THE US 3 G GROUP, 3 G DAILY OF STANOL ESTERS LOWERED TC AND LDL-C LEVELS BY 6.4% AND 10.1%, RESPECTIVELY. THERE WAS A DOSE-DEPENDENT RESPONSE COMPARED WITH 2 G DAILY (US 2 G). TRIGLYCERIDE AND HIGH-DENSITY LIPOPROTEIN CHOLESTEROL LEVELS WERE UNCHANGED. THE INCIDENCE OF ADVERSE EFFECTS WAS NOT DIFFERENT FROM PLACEBO. SERUM VITAMIN A AND 25-HYDROXY-VITAMIN D LEVELS WERE NOT EFFECTED. STANOL ESTERS LOWERED TC AND LDL-C LEVELS IN A MILDLY HYPERCHOLESTEROLEMIC US POPULATION WITHOUT EVIDENCE OF ADVERSE EFFECTS. IT MAY BE A USEFUL DIETARY ADJUNCT TO LOWER CHOLESTEROL. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |