Experiment 647075
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | LEE,AJ: CHAN,WK: HARRALSON,AF: BUFFUM,J: BUI,BCC:. (1999). THE EFFECTS OF GRAPEFRUIT JUICE ON SERTRALINE METABOLISM: IN INVITRO AND IN VIVO STUDY.. 21(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | MEAN SERUM SERTRALINE LEVELS WERE DETERMINED IN 5 PATIENTS WITH A HISTORY OF DEPRESSION (4 MALES AND 1 FEMALE). THE MEAN AGE OF THE PATIENTS WAS 68.6 YEARS, THERE MEAN WEIGHT WAS 69.6 KG, AND THEIR MEAN SERTRALINE DOSAGE WAS 55 MG/D. THE RESULTS OF THE IN VIVO STUDY APPEARED TO BE CONSISTENT WITH THE IN VITRO FINDINGS, IN THAT MEAN(+/- SD) SERUM SERTRALINE TROUGH LEVELS INCREASED SIGNIFICANTLY FROM 13.7 +/- 4.9 MICRO/L BEFORE TO 20.2 +/- 4.4 MICRO/L (P = 0.047) AFTER ADMINISTRATION OF GRAPEFRUIT JUICE. THUS THE IN VITRO STUDY DEMONSTRATED THAT GRAPEFRUIT JUICE CAN INHIBIT THE METABOLISM OF SERTRALINE. A LARGER STUDY IS WARRANTED TO SUBSTANTIATE THE CLINICAL SIGNIFICANCE OF THE IN VIVO FINDINGS. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | FRUIT JUICE |