Experiment 647078
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | WESTER,I:. (1999). DOSE RESPONSIVENESS TO PLANT STANOL ESTERS.. 1() |
| Amount utilized | |
| Compound isolated | |
| Disease | DIETARY INTAKE OF PLANT STANOL ESTERS IN AMOUNTS RANGING FROM 0.8 TO 4.0 G.DAY-1 (CALCULATED AS FREE STANOL) REDUCES CHOLESTEROL ABSORPTION AND CAUSES SINGIFICANT REDUCTIONS IN SERUM LOW-DENSITY LIPOPROTEIN (LDL) CHOLESTEROL LEVELS. PLANT STANOL ESTERS ARE HYDROLYZED IN THE SMALL INTESTINE MOST PROBABLY BY PANCREATIC CHOLESTROL ESTERASE TO FREE PLANT STANOL, THE FORM THAT ACTIVELY REDUCES CHOLESTEROL ABSORPTION. EARLY STUDIES WITH FREE PLANT STEROLS INDICATED A MAXIMUM CHOLESTEROL- LOWERING EFFECT WITH A DAILY INTAKE OF 3 G. PUBLISHED STUDIES INDICATE THAT CONSUMPTION OF MORE THAN 2.5 G.DAY-1 OF PLANT STANOL TAKEN AS ESTERS DOES NOT INCREASE THE CHOLESTEROL-LOWERING EFFECT. A COMPILATION OF DATA FROM PUBLISHED STUDIES INDICATES A CURVILINEAR DOSE RESPONSE WITH A CLEAR LEVELING-OFF AT AN INTAKE OF PLANT STANOL ESTERS EQUIVALENT TO ABOUT 2.2 G.DAY-1 PLANT STANOL; THIS HAS RECENTLY BEEN VERIFIED IN A NEW STUDY. HIGHER INTAKES OF PLANT STANOL ESTERS COULD HAVE EFFECTS SIMILAR TO VISCOUS DIETARY FIBRES ON LIPID EMULSIFICATION AND LIPOLYSIS DUE TO THE HIGH VISCOSITY OF PLANT STANOL ESTERS. SUCH EFFECTS COULD FURTHER POTENTIATE THE CHOLESTEROL-LOWERING EFFECTS OF PLANT STANOL ESTERS AT HIGHER DAILY INTAKES. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |