Experiment 647084
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | PLAT,J: MENSINK,RP:. (2000). VEGETABLE OIL BASED VERSUS WOOD BASED STANOL ESTER MIXTURES: EFFECTS ON SERUM LIPIDS AND HEMOSTATIC FACTORS IN NON-HYPERCHOLESTEROLEMIC SUBJECTS.. 148(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | A PINE WOOD BASED STANOL ESTER MIXTURE-COMPOSED OF SITOSTANOL (92%) AND CAMPESTANOL (8%) EFFECTIVELY LOWERS CHOLESTEROL ABSORPTION AND CONSEQUENTLY LDL-CHOLESTEROL CONCENTRATIONS. IT HAS BEEN POSTULATED THAT THE LESS ABSORBABLE PLANT STEROLS REDUCE CHOLESTEROL ABSORPTION MORE EFFECTIVELY. AS SITOSTANOL IS ABSORBED LESS THAN CAMPESTANOL, WE DECIDED TO EXAMINE IF A VEGETABLE OIL BASED STANOL ESTER MIXTURE WITH 68% SITOSTANOL AND 32% CAMPESTANOL IS LESS EFFECTIVE THAN THE WOOD BASED STANOL ESTER MIXTURE. FOR THIS, 112 NON-HYPERCHOLESTEROLEMIC MEN AND WOMEN CONSUMED FOR 4 WEEKS A RAPESEED OIL (LEAR) BASED MARGARINE AND SHORTENING. FOR THE NEXT 8 WEEKS. 42 SUBJECTS CONTINUED WITH THESE PRODUCTS, WHILE THE OTHER SUBJECTS RECEIVED PRODUCTS WITH A VEGETABLE OIL (N=36) OR A PINE WOOD BASED STANOL ESTER MIXTURE (N=34). CONSUMPTION OF 3.8 G VEGETABLE OIL BASED STANOLS (2.6 G SITOSTANOL PLUS 1.2 G CAMPESTANOL) LOWERED LDL CHOLESTEROL 14.6+/-8.0%(-0.37 MMOL/1; VS.THE CONTROL GROUP; P<0.001; 95% CI FOR THE DIFFERENCE. -0.22 TO -0.51 MMOL/1). FOUR GRAMS PINE WOOD BASED STANOLS (3.7 G SITOSTANOL PLUS 0.3 G CAMPESTANOL) SHOWED A COMPARABLE DECREASE OF 12.8+/-11.2%(-0.34 MMOL/1; P<0.001L 95% CI-0.18 TO -0.51 MMOL/1). DECREASES IN LDL CHOLESTEROL WERE NOT DIFFERENT BETWEEN THE TWO EXPERIMENTAL GROUPS(P=0.793), WHILE APOE GENOTYPE DID NOT HAVE A MAJOR IMPACT ON THIS HYPOCHOLESTEROLEMIC RESPONSE. SERUM HDL CHOLESTEROL AND TRIACYLGLYCEROL CONCENTRATIONS WERE NOT CHANGED. THE DECREASES IN APO B IN BOTH EXPERIMENTAL GROUPS DIFFERED SIGNIFICANTLY (P<0.001) FROM CHANGES IN THE CONTROL GROUP. COAGULATION AND FIBRINOLYTIC PARAMETERS WERE NOT AFFECTED. WE THEREFORE CONCLUDE THAT VEGETABLE OIL AND WOOD BASED STANOL ESTER MIXTURES, WITH A DIFFERENT SITOSTANOL CAMPESTANOL RATIO, HAVE SIMILAR LDL CHOLESTEROL LOWERING EFFECTS IN A NON-HYPERCHOLESTEROLEMIC POPULATION. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |