Experiment 647105

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismEmpty organism
CitationPLAT,J: VAN ONSELEN,ENM: MENSINK,RP:. (1999). DIETARY PLANT STANOL ESTER MIXTURES. EFFECTS ON SAFETY PARAMETERS AND ERYTHROCYTE MEMBRANE FATTY ACID COMPOSITION IN NON-HYPERCHOLESTEROLAEMIC SUBJECTS.. 1999(1)
Amount utilized
Compound isolated
DiseaseWE EXAMINED THE EFFECTS OF LOW ERUCIC ACID RAPESEED (LEAR) OIL-BASED MARGARINES AND SHORATENINGS ENRICHED WITH TWO DIFFERENT PLANT STANOL ESTER MIXTURES ON CHANGES IN THE FATTY ACID COMPOSITION OF ERYTHROCYTE NEUTRAL PHOSPHOLIPIDS. COMPARED WITH PRE-STUDY VALUES, PROPORTIONS OF A-LINOLENIC ACID, EICOSAPENTAENOIC ACID, DOCOSAHEXAENOIC ACID, LINOLEIC ACID AND OLEIC ACID INCREASED MAINLY AT THE EXPENSE OF THE PROPORTION OF SATURATED FATTY ACIDS. THESE EFFECTS WERE NOT DEPENDENT ON THE PRESENCE OF PLANT STANOLS IN THE MARGARINES OR SHORTENINGS. IN TWO STUDIES WITH 3 DIFFERENT PLANT STANOL ESTER MIXTURES (INTAKE OF 2.5-4.0 G.DAY-1 PLANT STANOLS), NO ADVERSE EFFECTS WERE FOUND ON LIVER OR KIDNEY FUNCTION, C-REACTIVE PROTEIN CONCENTRATIONS AND HAEMATOLOGICAL PARAMETERS. FORTHERMORE, THERE WAS NO EVIDENCE THAT ANY PHYSICAL INCONVENIENCE, AS REPORTED IN QUESTIONNAIRES, WAS RELATED ATO INTAKE OF PLANT STANOL ESTERS. SHORT-TERM CONSUMPTION OF PLANT STANOL ESTER DOES NOT CAUSE ANY ADVERSE EFFECTS IN STILL WARRANTED WITH LONG-TERM STANOL ESTER CONSUMPTION.
Dose amountVAR
Number1
Qualitative resultINACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
GenderGIVEN TO BOTH SEXES