Experiment 647107
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | GYLLING,H:. (1999). STUDIES OF PLANT STANOL ESTERS IN DIFFERENT PATIENT POPULATIONS.. 1999(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFICACY AND SAFETY OF PLANT STANOL ESTERS DISSOLVED IN MARGARINE ALONE OR COMBINED WITH STATINS, NEOMYCIN OR STATINS PLUS CHOLESTYRAMINE WERE INVESTIGATED IN CHILDREN WITH FAMILIAL HYPERCHOLESTEROLAEMIA(FH) AND IN PATIENTS WITH TYPE 2 DIABETES MELLITUS(DM). IN FH CHILDREN, LOW-DENSITY LIPOPROTEIN(LDL) CHOLESTEROL WAS SIGNIFICANTLY REDUCED BY 15-18%. HIGH-DENSITY LIPOPROTEIN(HDL) CHOLESTEROL AND TRIGLYCERIDES WERE UNCHANGED. SERUM PLANT STEROL CONCENTRATIONS WERE SIGNIFICANTLY REDUCED BY 29-42%. IN DM, STANOL ESTERS REDUCED LDL CHOLESGTEROL LEVELS BY 9% AND INCREASED HDL CHOLESTEROL LEVELS BY 11%(BOTH P<0.05). METABOLIC ALTERATIONS INCLUDED AN INHIBITION OF CHOLESTEROL ABSORPTION EFFICIENCY. A COMPENSATORY INCREASE IN CHOLESTEROL SYNTHESIS AND INHIBITION OF NEW LDL PARTICLE PRODUCTION. STANOL ESTERS ADDED TO STATIN THERAPY LOWERED LDL CHOLESTEROL LEVELS BY 12-20%(P<0.001). NEOMYCIN AND STANOL ESTERS SIGNIFICANTLY LOWERED LDL CHOLESTGEROL LEVELS BY 37% AND TRIGLYCERIDES BY 30% STATIN, CHOLESTYRAMINE AND STANOL ESTERS TOGETHER LOWERED LDL CHOLESTEROL LEVELS BY 67% FROM BASELINE(P<0.05) AND INCREASED HDL CHOLESTEROL LEVELS BY 11%(P<0.05). IN ALL STUDIES STANOL ESTERS WERE WELL TOLERATED WHEN USED ALONE OR IN COMBINATION WITH OTHER DRUGS. STANOL ESTERS ARE WELL TOLERATED AND EFFECTIVE ON CHILDREN WITH FH AND IN ADULTS WITH DM. STANOL ESTERS COMBINED WITH STATINS, NEOMYCIN OR CHOLESTYRAMINE POTENTIATE THE CHOLESTEROL-LOWERING EFFECT. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |