Experiment 647130

Worktypes

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismVitis vinifera (VITACEAE)
CitationNUTTALL,SL: KENDALL,MJ: BOMBARDELLI,E: MORAZZONI,P:. (1998). AN EVALUATION OF THE ANTIOXIDANT ACTIVITY OF A STANDARDIZED GRAPE SEED EXTRACT, LEUCOSELECT.. 23(5)
Amount utilized
Compound isolated
DiseaseA SINGLE-BLINDED RANDOMISED, PLACEBO-CONTROLLED CROSS-OVER STUDY WAS UNDERTAKEN IN 20 YOUNG VOLUNTEERS. SUBJECTS WERE GIVEN 2 CAPSULES CONTAINING 300 MG OF GRAPE PROCYANIDIN EXTRACTS (LEUCOSELET-PHYTOSOME) OR PLACEBO DAILY FOR 5 DAYS. BLOOD SAMPLES WERE TAKEN AT THE START OF THE STUDY AND END OF THE STUDY AND ASSAYED FOR ANTIOXIDANT ACTIVITY AND VITAMINS C AND E LEVELS. AFTER A WASHOUT PERIOD OF AT LEAST 2 WEEKS, THE STUDY WAS REPEATED WITH THE SECOND TREATMENT. THE EXTRACT HAD NO EFFECT ON SERUM VITAMINS C AND E LEVELS BUT INCREASED SERUM TOTAL ANTIOXIDANT ACTIVITY (TAC). ON DAY 5, TAC INCREASED FROM 408-1 +/- 22.9 TO 453-3+/- 453.3 MICRO/MOL/L TROLOX EQUIVALENTS 1 HOUR POSTDOSE. A COMMERCIAL PRODUCT, LEUCOSELECT-PHYTOSOME, WAS USED.
Dose amount600.0 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractSEEDS
GenderGIVEN TO BOTH SEXES