Experiment 647134

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismCitrus paradisi (RUTACEAE)
CitationTAKANAGA,H: OHNISHI,A: MATSUO,H: MURAKAMI,H: SATA,H: KURODA,K: URAE,A: HIGUCHI,S: SAWADA,Y:. (2000). PHARMACOKINETIC ANALYSIS OF FELODIPINE-GRAPEFRUIT JUICE INTERACTION BASED ON AN IRREVERSIBLE ENZYME INHIBITION MODEL.. 49(1)
Amount utilized
Compound isolated
DiseaseFELODIPINE AS A MODEL DRUG CONSTRUCTED A PHARMACOKINETIC MODEL BASED ON IRREVERSIBLE INHIBITION OF INTESTINAL CYTOCHROME P450 3A4 BY GRAPEFRUIT JUICE(GFJ). GFJ-FELODIPINE INTERACTION INCREASES WITH INCREASING FREQUENCY AND AMOUNT OF GFJ INGESTION.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractFRUIT JUICE
GenderGIVEN TO BOTH SEXES