Experiment 648416
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | MIRON,T: RABINKOV,A: MIRELMAN,D: WILCHEK,M: WEINER,L:. (2000). THE MODE OF ACTION OF ALLICIN: ITS READY PERMEABILITY THROUGH PHOSPHOLIPID MEMBRANES MAY CONTRIBUTE TO ITS BIOLOGICAL ACTIVITY.. 1463(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | ALLICIN (DIALLY THIOSULFINATE) IS THE MANIN BIOLOGICALLY ACTIVE COMPONENT OF THE FRESHLY CRUSHED GARLIC EXTRACTS. IN THE PRESENT WORK THE ABILITY OF ALLICIN TO CROSS THROUGH MEMBRANES (ARTICIAL AND BIOLGICAL) WAS STUDIED. PARTITION COEFFICIENT OF ALLICIN IN WATER/OCTANOL, WATER/HEXADECANE AND WATER/PHOSPHOLIPIDS MIXTURES WERE DETERMINED. USING PHOSPHOLIPID VESCILES LOADED WITH HYDROPHILIC THIOLS (REDUCED GLUTATHIONE OR 2-NITRO-5-THIOBENZOATE), WE OBSERVED THAT ALLICIN FREELY PERMEATES THROUGH PHOSPHOLIPID BIALYERS AND INTERACTS WITH THE SH GROUPS. THE REACTION RATE OF ALLICIN WITH SH CONTAINING MOLECULES AFTER CROSSING THE MEMBRANE WAS THE SAME AS IN SOLUTION. FAST DIFFUSIN AND PERMEATION OF ALLICIN ACROSS HUMAN RED BLOOD CELL MEMBRANES WAS ALSO DEMOSTRATED. ALLICIN DOES NOT INDUCE LEAKAGE, FUSION OR AGGREGATION OF MEMBRANE. THE HIGH PERMEABILITY OF ALLICIN THROUGH MEMBRANES MAY GREATLY ENHANCE THE INTRACELLULAR INTERACTION WITH THIOLS. |
| Dose amount | 250.0 MICROLITERS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Dose expression | CONC USED |