Experiment 648620
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | LEE,KT: KIM,JI: RHO,YS: CHANG,SG: JUNG,JC: PARK,JH: PARK,HJ: MIYAMOTO,KI:. (1999). HYPERICIN INDUCES BOTH DIFFERENTIATION AND APOPTOSIS IN HUMAN PROMYELOCYTIC LEUKEMIA HL-60 CELLS.. 22(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | HYPERICIN IS A UNIQUE PHOTOSENSITIZING PLANT PIGMENT AND HAS BEEN SEPERATELY REPORTED TO INDUCE DIFFERENTIATION AND APOTOSIS IN NEOPLASTIC CELLS. IN THIS STUDY, WE EXAMINED THE RELATIONSHIP BETWEEN ACTIVITIES TO INDUCED DIFFERENTIATION AND APOPTOSIS IN HUMAN PORMYELOCYTIC LEUKEMIA HL-60 CELLS, AT A CONCENTRATION RANGE OF 0.15 TO 0.2 MICROGRAM . WHEN TREATED WITH HYPRICIN, THE CELL RATIO REDUCIBLE OF NITROBLUE TETRAZOLLUM WAS SIGNIFICANTLY INCREASED AND THE CELL SIZE WAS ENLARGED BY FLOW CYTOMETRY ANALYSIS. HYPERICIN ALSO SIGNIFICANTLY INCREASED THE RATIO OF THE CELLS, WHICH WERE OF POSITIVE ALPHA-NAPHTHYL ACETATE ESTERASE ACTIVITY AND PHAGOCYTIC ACTIVITY, WHEREAS IT HARDLY INFLUENCED THE NAPHTHOL AS-D CHLOROACETATE ESTERASE ACTIVITY IN THE CELLS, AS WELL AS 1 ALPHA, 25(OH)2D3 (10 NM). IN ADDITION, HYPERICIN INCREASED HYPODIPLOID NUCLEI AND CAUSED A NUCLEOSOMAL LADDER. THESE RESULTS INDICATED THAT HYPERICIN INDUCES BOTH DIFFERENTIATION TOWARD MONOCYTE/ MACROPHAGE LINEAGE AND APOPTOSIS IN HL-60 CELLS. |
| Dose amount | 0.15 MICROMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CELL CULTURE |
| Dose expression | CONC USED |