Experiment 652691
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ROUTE NOT GIVEN |
| Organism | Tanacetum parthenium (ASTERACEAE) |
| Citation | KULKAMI,SK: JAIN,NK:. (1999). FEVERFEW: ANCIENT REMEDY FOR MULTIPLE DISORDERS.. 24(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | PARTHENOLIDE AND FEVERFEW EXTRACT INHIBITED 5-HT SECRETION BUT NOT PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PLATELET AGGREGATION, SUGGESTING THAT THERE MAY BE INTERACTIONS BETWEEN PARTHENOLIDE AND PROTEIN KINASE. IT HAS BEEN REPORTED THAT PARTHENOLIDE HAS 5-HT ANTAGONISTIC ACTIVITY WHICH MAY CONTRIBUTE TO ITS PROPHYLACTIC POTENTIAL IN MIGRAINE THERAPY. PARTHENOLIDE WAS ALSO SHOWN TO NONSELECTIVELY RENDER SMOOTH MUSCLE LESS RESPONSIVE TO ENDOGENOUS SUBSTANCES SUCH AS NORADRENALINE, ACETYLOCHLINE , BRADYKININ, PROSTAGLANDINS, HISTAMINE AND SEROTONIN IN A NON COMPETITIVE MANNER. THESE ANTAGONISTIC PROPERTIES ARE CONSISTENT WITH AN ANTIMIGRAINE EFFECT OCCURRING VIA INHIBITION OF EXTRACELLULAR CALCIUM INFLUX INTO VASCULAR SMOOTH MUSCLE CELLS. |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | LEAVES |