Experiment 653534
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | ZIMMERMAN,AM: MURER-ORLANDO,ML: RICHER,CL:. (1986). EFFECT OF CANNABINOIDS ON SPERMATOGENESIS IN VIVO: A CYTOLOGICAL STUDY.. 45(180) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE CYTOGENIC EFFECTS OF TETRAHYDROCANNABINOL (THC) AND CANANBINOL (CBN) (10 MG/KG) WERE INVESTIGATED IN HYBRID MICE OF GENOTYPE (C57BL X C3M(F1. MICE WERE TREATED FOR 5 CONSECTIVE DAYS WITH THE SPECIFIC CANNABINOID; 16 DAYS AFTER THE LAST TREATMENT MENT THE MEIOTIC CELLS WERE EVALUATED. ANALYSIS OF THE SPERMATOCYTE BIVALENTS AT THE FIRST MEIOTIC METAPHASE FAILED TO REVEAL ANY NUMERICAL OR STRUCTURAL ABNORMALITY. CONTARY TO PREVIOUS REPORTS WE FAILED TO FIND ANY MAJOR MEIOTIC ABNORMALITIES ASSOCIATED THC AND CBN TREATMENTS. THERE WAS NO EVIDENCE OF RING OR CHAIN FIGURES. THE CENTROMETIC BANDING PROCEDURE (C BANDING) WAS USED TO SUPPORT OBSERVATIONS OF GIEMAS STAINED CELLS. IT HAS PREVIOUSLY BEEN REPORTED THAT CANNABINOIDS SUPPRESS THE INCORPORATION OF 3H-URIDINE INTO PACHYTENE SPERMATOCYTES AND ROUND SPERMATIDS; THE ABSENCE OF CHROMOSOME ABERRATIONS IN THE PRESENT STUDY SUGGESTS THAT AN ADVERSE EFFECT APPEARS TO BE PRESENT, BUT MAY BE AT A LEVEL OTHER THAN CYTOGENETIC. |
| Dose amount | 10.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |