Experiment 66684
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Glycine max (FABACEAE) |
| Citation | PELLETIER,X: BELBRAOUET,S: MIRABEL,D: MORDRET,F: PERRIN,JL: PAGES,X: DEBRY,G:. (1995). A DIET MODERATELY ENRICHED IN PHYTOSTEROLS LOWERS PLASMA CHOLESTEROL COONCENTRATIONS IN NORMOCHOLESTEROLEMIC HUMANS.. 39(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | 12 NORMOLIPIDIC HEALTHY HUMAN SUBJECTS WERE FED A DIET WITH OR WITHOUT ADDITIONAL SOYBEAN PHYTOSTEROLS FOR 4 WEEKS IN A CROSSOVER DESIGN. THE ORDER OF THE TREATMENTS WAS RANDOMIZED. PHYTOSTEROLS WERE ADDED TO THE DIET BLENDED IN BUTTER. THE DIETARY RATIO CHOLESTEROL:PHYTOSTEROLS WAS 0.7 DURING THE CONTROL PERIOD (4365 MG CHOLESTEROL/DAY AND 29 MG PHYTOSTEROLS/DAY) AND 1.88 DURING THE PHYTOSTEROLS PEROID (410 MG CHOLESTEROL/DAY AND 740 MG PHYTOSTEROLS/DAY). BLOOD CHOLESTEROL WAS 10% LOWER AFTER SUBJECTS CONSUMED THE PHYTOSTEROL-ENRICHED DIET THAN WHEN THEY CONSUMED THE CONTROL DIET (P<0.001), WHICH WAS DUE TO A 15% LDL CHOLESTEROL DECREASE (P<0.001). THE HDL CHOLESTEROL:LDL CHOLESTEROL RATIO WAS MARKEDLY ENHANCED(+25%) (P<0.01). THESE FINDINGS SUGGEST THAT A SIGNIFICANT LOWERING OF PLASMA TOTAL AND LDL CHOLESTEROL CAN BE EFFECTED BY A MODEST DIETARY INTAKE OF SOYBEAN PHYTOSTEROLS. |
| Dose amount | 740.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | SEED OIL |
| Gender | MALE |